Paraoxonase Activities in Metabolic Syndrome in Children and Adolescents
نویسندگان
چکیده مقاله:
Background: Metabolic syndrome (MetS) is a collection of various interrelated risk factors that appear to have an impact as development of atherosclerotic cardiovascular disease (CVDs). Epidemic of childhood and adolescent’s obesity has increased interest in the metabolic syndrome (MS) due to the potential projection into adulthood. The prevalence of MS in adolescents has been estimated to be 6.7% in young adults and 4.2% in adolescents. We aimed to study the MetS in children and adolescents with respect to metabolic changes. Methods: The international Diabetes Federation criteria were used for the selection of cases. Serum paraoxonase 1 (PON1) activities were measured using spectrophotometer. Statistical analysis was done using MyStat statistical software. Results: Serum PON1 arylesterase (ARE) and lactonase (LACT) activities were found to be reduced significantly in patients with MetS than in controls. Regression analysis showed a significant correlation between PON1 activities and body mass index. Area under curve (AUC) found to increase from HDL to PON1 ARE to PON1 LACT. Conclusions: From the present study, it is clear that in children and adolescents, reduction in PON1 activities in MetS is mainly due either to abnormalities with synthesis or secretion of HDL cholesterol or oxidative stress as a consequence of excess production of the free radicals. This study also iterates that it is the quality and not the quantity of HDL cholesterol which is important while studying the pathophysiology of MetS.
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متن کامل
Metabolic Syndrome in Children and Adolescents
increased from about 5% in the 1960s and 1970s to 17% in 2003/04, whereas no further increase has been shown until 2009/10 [1, 2]. Similarly, the prevalence rates in Europe and Canada have neither increased nor declined between 2002 and 2010 but are in a state of high-level stagnation [3, 4]. Accordingly, data from the ‘Kinderund Jugendgesundheitssurvey’ (KiGGS) reveals that roughly 9% of child...
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متن کاملThe metabolic syndrome in children and adolescents.
The metabolic syndrome was recently defined by the Adult Treatment Panel III. Despite a lack of uniform definition of the syndrome in pediatrics, recent studies have shown that the syndrome develops during childhood and is highly prevalent among overweight children and adolescents. The hypothesized central role of insulin resistance and obesity as a common underlying feature of the metabolic sy...
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عنوان ژورنال
دوره 9 شماره None
صفحات 116- 120
تاریخ انتشار 2018-01
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